Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that two prebiotics, mucin and inulin, slowed the growth of melanoma in mice by boosting the immune system’s ability to fight cancer. In contrast to probiotics, which are live bacterial strains, prebiotics are “food” for bacteria and stimulate the growth of diverse beneficial populations. The study, published today in Cell Reports, provides further evidence that gut microbes have a role in shaping the immune response to cancer, and supports efforts to target the gut microbiome to enhance the efficacy of cancer therapy.
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Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth
Yan Li, Lisa Elme´ n, Igor Segota, Tao Long, Scott N. Peterson, Ze’ev A. Ronai