Bone, not adrenaline, drives fight or flight response

Bone, not adrenaline, drives fight or flight response

Bone, not adrenaline, drives fight or flight response

A new study from Columbia researchers suggests that bony vertebrates can’t muster this response to danger without the skeleton. The researchers found in mice and humans that almost immediately after the brain recognizes danger, it instructs the skeleton to flood the bloodstream with the bone-derived hormone osteocalcin, which is needed to turn on the fight or flight response

Julian Meyer Berger, Parminder Singh, Lori Khrimian, Donald A. Morgan, Subrata Chowdhury, Emilio Arteaga-Solis, Tamas L. Horvath, Ana I. Domingos, Anna L. Marsland, Vijay Kumal Yadav, Kamal Rahmouni, Xiao-Bing Gao, Gerard Karsenty. Mediation of the Acute Stress Response by the Skeleton. Cell Metabolism, 2019; DOI: 10.1016/j.cmet.2019.08.012

#osteocalcin #stress #asr

https://www.sciencedirect.com/science/article/pii/S1550413119304413?via%3Dihub#fig2



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