Resveratrol displayed neuroprotective effects against corticosterone by inhibiting the expression of PDE4. The research lays the groundwork for the use of the compound in novel antidepressants.
Xia Zhu, Wenhua Li, Yongkun Li, Wenhua Xu, Yirong Yuan, Victor Zheng, Hanting Zhang, James M. O’Donnell, Ying Xu, Xiaoxing Yin. The antidepressant- and anxiolytic-like effects of resveratrol: Involvement of phosphodiesterase-4D inhibition. Neuropharmacology, 2019; 153: 20 DOI: 10.1016/j.neuropharm.2019.04.022
Resveratrol, pde4, phosphodiesterase, antidepressant, anxiolytic, anxiety, depression, cyclic adenosine monophosphate, antidepressant, Corticosterone, stress, antistress, neuroprotective, enzyme