School vacations and humidity linked to multiple waves of influenza in Mexico during the 2009 H1N1 pandemic

Public Release: 20-Aug-2015

PLOS

Scientists studying the 2009 A/H1N1 influenza pandemic have found that the inconsistent regional timing of pandemic waves in Mexico was the result of interactions between school breaks and regional variations in humidity.

The research published in PLOS Computational Biology, led by Dr. James Tamerius at the University of Iowa and Dr. Gerardo Chowell at Georgia State University, applied mathematical models to understand the social and environmental processes that generated two distinct pandemic outbreaks (“waves”) in Mexico during the summer and fall of 2009.

The summer wave occurred in the tropical southeastern states of Mexico, whereas the larger fall wave occurred in the central and northern states. The models suggest that high levels of humidity favored the rapid spread of influenza in the tropical states that led to the early summer wave. On the other hand, moderate levels of humidity slowed transmission in the central and northern states precluding a pandemic wave prior to summer break. The summer break reduced the transmission rate by an estimated 14% thereby delaying the pandemic wave in the central and northern states until students returned to school in August. These processes can explain the two major and distinct pandemic waves that affected the different regions.

The relationship between humidity and pandemic influenza transmission found in this study is consistent with the relationship observed for seasonal influenza. This suggests that a greater understanding of the mechanisms that drive inter-pandemic influenza epidemics may increase our capacity to predict the timing of major outbreaks associated with novel pandemic influenza viruses in the future.

All works published in PLOS Computational Biology are Open Access, which means that all content is immediately and freely available. Use this URL in your coverage to provide readers access to the paper upon publication: http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004337

Press-only preview: https://www.plos.org/wp-content/uploads/2015/08/pcbi.1004337.pdf

Contact: James Tamerius
Address: University of Iowa
Department of Geographical and Sustainability Sciences
University of Iowa
Iowa City, 52245
UNITED STATES
Phone: (520) 780-7650
Email: james-tamerius@uiowa.edu

Citation: Tamerius J, Viboud C, Shaman J, Chowell G (2015) Impact of School Cycles and Environmental Forcing on the Timing of Pandemic Influenza Activity in Mexican States, May-December 2009. PLoS Comput Biol 11(8): e1004337. doi:10.1371/journal.pcbi.1004337

Funding: Funding was provided by the NIH Models of Infectious Disease Agent Study program through cooperative agreement 1U54GM088558 (JT, JS), as well as NIEHS Center grant ES009089 (JS), the RAPIDD program of the Science and Technology Directorate, US Department of Homeland Security (JS), and the in-house influenza research program of the Fogarty International Center, NIH, funded by the Office of Global Affairs’ International Influenza Unit,

Office of the Secretary, US Department of Health and Human Services. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: JS discloses consulting for JT and Axon Advisors and partial ownership of SK Analytics.

About PLOS Computational Biology

PLOS Computational Biology features works of exceptional significance that further our understanding of living systems at all scales through the application of computational methods. All works published in PLOS Computational Biology are Open Access. All content is immediately available and subject only to the condition that the original authorship and source are properly attributed. Copyright is retained. For more information follow @PLOSCompBiol on Twitter or contact ploscompbiol@plos.org.

About PLOS

PLOS is a nonprofit publisher and advocacy organization founded to accelerate progress in science and medicine by leading a transformation in research communication. For more information, visit http://www.plos.org.

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Categories: . Enhanced Disease Transmission

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