Asian herb holds promise as treatment for Ebola virus disease
– Researchers announced that a small molecule called Tetrandrine derived from an Asian herb has shown to be a potent small molecule inhibiting infection of human white blood cells in vitro or petri dish experiments and prevented Ebola virus disease in mice.
The team found Tetrandrine protected mice from disease without obvious side effects and was the best candidate for further animal testing, because it was the most potent compound tested, gave little evidence of cytotoxicity and required a smaller dose to be effective and tolerated. Blood Pressure drugs kind of worked similar “When we tested in mice, the drugs stopped virus replication and saved most of them from disease,” Davey said. Essentially, this drug shows an ability to stop the virus before it has a chance interact with cellular factors, thus stopping the virus from continuing its infection process.
* Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment Science 27 February 2015: Vol. 347 no. 6225 pp. 995-998 DOI: 10.1126/science.1258758